Deep Learning for Prediction of Progression and Recurrence in Nonfunctioning Pituitary Macroadenomas: Combination of Clinical and MRI Features

ObjectivesA subset of non-functioning pituitary macroadenomas (NFMAs) may exhibit early progression/recurrence (P/R) after tumor resection.The purpose of this study was to apply deep learning (DL) algorithms for prediction of P/R in NFMAs.MethodsFrom June 2009 to Chime December 2019, 78 patients diagnosed with pathologically confirmed NFMAs, and wh

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Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

Glucocorticoids are widely used as an ophthalmic medication.A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway.We report that netarsudil, a rho-kinase Dishwasher Thermostat inhibitor, decreased glucocorticoid-induced ocular hypertension in patients whos

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